Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology

Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology

Blog Article

Angiopoietins 1−4 (Ang1−4) represent an important family of growth factors, whose activities are mediated through the tyrosine kinase receptors, Tie1 and Tie2.The best characterized are angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2).Ang1 is a potent angiogenic growth factor signaling through Tie2, whereas Ang2 was initially identified as a vascular disruptive agent with antagonistic activity through the same receptor.Recent data demonstrates sequal eclipse 5 battery that Ang2 has context-dependent agonist activities.

Ang2 plays important roles in physiological processes and the deregulation of its expression is characteristic of several diseases.In this review, we summarize the activity apac1/60/1/cw of Ang2 on blood and lymphatic endothelial cells, its significance in human physiology and disease, and provide a current view of the molecular signaling pathways regulated by Ang2 in endothelial cells.